I would look at the Lyman guide with care.  Some loads listed are great, and some border on dangerous.  I recall the case of someone who destroyed a rifle recently and cited the load from the Lyman manual.  Upon checking, they Lyman 49th did list the load he used, and further checking of Hornady and Sierra data placed his load at beyond dangerous levels.  In short, either the Lyman manual had a serious typo, or the data was just flat bad!  The Hornady 9th and 10th editions are my bible!

FWIW, a good load for the Krag using 220 gr bullets and 4350 is right at 40.0 grains.  There really is no reason to go any higher!