I would be very careful of any load that exceeds 40,000 cup!!!  If you are using the Lyman book, stick to established loads.  A lot of us use 40.0 grains of 4350 with our 220 GR bullets.  4350 is a nice slow burning powder which approximates the original .30 US round very nicely.  There is also virtually zero chance of a double charge, as the case is more than 3/4 full with the 40 grain load (a double charge would mean that you're spilling powder all over the bench, LOL).