H4350 is a little slower burn and works better for me on the heavier 220gr weight bullet. I use the H4895 for my lighter bullets on the Krag. You could likely use the H4895 in other lighter loads as well. I use the same Sierra 175 BTHP but matched with IMR4895 for my 30-06 loads which closely matches the old LC Match ammo. Mostly preference, but that’s what I’ve found works for me.